Anti-cancer effects of curcumin (CUR) and tetrahydrocurcumin (THC) – Science

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“Anticancer potential of curcumin: preclinical and clinical studies.” http://www.ncbi.nlm.nih.gov/pubmed/12680238

“Tetrahydrocurcumin is more effective than curcumin in preventing… colon carcinogenesis. Tetrahydrocurcumin (THC), a major metabolite of curcumin (CUR), has been demonstrated to be anti-cancerogenic and anti-angiogenic…these results demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary THC…”  http://www.ncbi.nlm.nih.gov/pubmed/21887819

“Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA.” http://www.ncbi.nlm.nih.gov/pubmed/18565284

“Plant-derived anticancer agents – curcumin in cancer prevention and treatment.”  http://www.ncbi.nlm.nih.gov/pubmed/23700916

“Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701520/

“Mechanisms of cancer chemoprevention by curcumin.” http://www.ncbi.nlm.nih.gov/pubmed/11370761 

“Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.” http://www.ncbi.nlm.nih.gov/pubmed/21928294

 “Synergistic anticancer activity of curcumin and catechin: an in vitro study using human cancer cell lines.” http://www.ncbi.nlm.nih.gov/pubmed/21780253 

“Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/23446753

“Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells.” http://www.ncbi.nlm.nih.gov/pubmed/22290509

 “Curcumin polymers as anticancer conjugates.” http://www.ncbi.nlm.nih.gov/pubmed/20591475

“Curcumin Potentiates The Ability of Sunitinib to Eliminate the VHL-lacking Renal Cancer Cells 786-O: Rapid Inhibition of Rb Phosphorylation as a Preamble to Cyclin D1 Inhibition.” http://www.ncbi.nlm.nih.gov/pubmed/23848205

 “RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER‑negative breast cancer models.” http://www.ncbi.nlm.nih.gov/pubmed/22971638

“ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells.” http://www.ncbi.nlm.nih.gov/pubmed/22890189

 “Inclusion complex of novel curcumin analogue CDF and β-cyclodextrin (1:2) and its enhanced in vivo anticancer activity against pancreatic cancer.” http://www.ncbi.nlm.nih.gov/pubmed/22322899

“Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells.” http://www.ncbi.nlm.nih.gov/pubmed/15700780

“Superior anticancer efficacy of curcumin-loaded nanoparticles against lung cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23786839

“Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.” http://www.ncbi.nlm.nih.gov/pubmed/21603867

“Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin.” http://www.ncbi.nlm.nih.gov/pubmed/23485682

 “Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.” http://www.ncbi.nlm.nih.gov/pubmed/18496811

“Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.” http://www.ncbi.nlm.nih.gov/pubmed/23847105

“Perspectives on new synthetic curcumin analogs and their potential anticancer properties.” http://www.ncbi.nlm.nih.gov/pubmed/23116312

“Synthesis and evaluation of curcumin-related compounds for anticancer activity.” http://www.ncbi.nlm.nih.gov/pubmed/22551677

 “Curcumin and its analogues: potential anticancer agents.” http://www.ncbi.nlm.nih.gov/pubmed/20027668

“Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665575/

“Highly active anticancer curcumin analogues.” http://www.ncbi.nlm.nih.gov/pubmed/17569206 

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