“Status epilepticus (SE) is a medical emergency associated with a high rate of mortality if not treated promptly.
Exogenous and endogenous cannabinoids have been shown to possess anticonvulsant properties both in vivo and in vitro.
Here we study the influence of endocannabinoid metabolism on the development of kainic acid-induced SE in guinea pigs.
The present study provides electrophysiologic and behavioral evidences that inhibition of endocannabinoid metabolism plays a protective role against kainic acid-induced SE and may be employed for therapeutic purposes.”