Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes.

“Adenylate cyclase in plasma membranes was inhibited by micromolar concentrations of delta 8-tetrahydrocannabinol and delta 9-tetrahydrocannabinol…

The inhibition of adenylate cyclase was specific for psychoactive cannabinoids, since cannabinol and cannabidiol produced minimal or no response…

Possible mechanisms for the effects of cannabinoid drugs on adenylate cyclase activity…”

http://www.ncbi.nlm.nih.gov/pubmed/6092901

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