“Accumulating evidence supports the role of the cannabinoid system in providing an antinociceptive effect in various painful conditions.
This effect is mediated through the Cannabinoid receptor 1 (CB1R) expressed on nociceptive afferent nerve terminals.
To investigate whether this receptor plays a similar role in dental pain, we studied the presence and distribution of CB1R in rat dental pulp.
CB1R was present on nerve fibers in rat dental pulp and possibly plays a role in dental pain mechanisms.
Interestingly, CB1R has recently been demonstrated in human dental pulp.
This strongly suggests that CB1R could be a therapeutic target for dental pain management.”