Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction.

Cover image volume 30, Issue 12“Cannabinoids are reported to rescue cocaine-induced seizures (CISs), a severe complication in cocaine users. However, the molecular targets for cannabinoid therapy of CISs remain unclear.

Here, we report that the systemic administration of cannabinoids alleviates CISs in a CB1/CB2-receptor-independent manner.

These findings suggest that using GlyR-hypersensitive cannabinoids may represent a potential therapeutic strategy for treating CISs.”

https://www.ncbi.nlm.nih.gov/pubmed/32209479

“Cannabinoids alleviate cocaine-induced seizures (CISs) by glycine receptors (GlyRs).”

https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30287-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124720302874%3Fshowall%3Dtrue

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