“Pain associated with cancer and tumor growth is often difficult to manage.”
“Cannabis sativa has a long history of use for management of pain.”
“In light of the adverse side effects of opioids, cannabinoid (CB) receptor agonists may provide an effective alternative for the treatment of cancer pain. The present study examined the potency and efficacy of synthetic CB1 and CB2 receptor agonists in a murine model of tumor pain.”
“Co-administering both CB receptor agonists attenuated mechanical hyperalgesia through a synergistic mechanism.”
“Together these data support the use of combined CB1 and CB2 receptor agonists in the development of strategies for the treatment of tumor related pain.”
“These data extend our previous findings that the peripheral cannabinoid receptors are a promising target for the management of cancer pain and mixed cannabinoid receptor agonists may have a therapeutic advantage over selective agonists.”
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