Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

“Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid which interacts with specific targets involved in carcinogenesis…

Here, we investigated whether CBG protects against colon tumorigenesis.

In vivo, CBG inhibited the growth of xenograft tumors as well as chemically-induced colon carcinogenesis.

CBG hampers colon cancer progression in vivo and selectively inhibits the growth of colorectal cancer cells, an effect shared by other TRPM8 antagonists.

CBG should be considered translationally in colorectal cancer prevention and cure.”

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