Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.

“Anandamide (AEA) is a lipid mediator that participates in the regulation of several reproductive functions.

This study investigated the endocannabinoid system in normal (NP) and preeclamptic (PE) placentas, and analyzed the potential functional role of AEA in the regulation of nitric oxide synthesis…

These data suggest that AEA may be one of the factors involved in the regulation of NOS activity in normal and preeclamptic placental villous.

Interestingly, the differential expression of NAPE-PLD and FAAH suggests that AEA could play an important role in the pathophysiology of PE.”


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