The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.

“Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta9-tetrahydrocannabinol (Delta9-THC)-induced antinociception in Freund’s adjuvant-induced arthritic and nonarthritic rats…

Our results indicate that morphine or Delta9-THC is equally potent and efficacious in both nonarthritic and arthritic rats.

Delta9-THC-induced antinociception…

We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release.”

http://www.ncbi.nlm.nih.gov/pubmed/15189765

http://www.thctotalhealthcare.com/category/arthritis/

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