“Cannabinoid system is a potential target for pain control. Cannabinoid receptor 1 (CB₁) activation play a role in the analgesic effect of cannabinoids once it is expressed in primary afferent neurons. This study investigates whether the anti-hyperalgesic effect of CB₁receptor activation involves P2×₃ receptor in primary afferent neurons. Our data suggest that the analgesic effect of CB₁ receptor activation is mediated by a negative modulation of the P2×₃ receptor in the primary afferent neurons.” https://www.ncbi.nlm.nih.gov/pubmed/28131783]]>