“Background: This study compared the efficacy and safety of integrative and conventional therapies for chronic insomnia.

Objective: To evaluate the effects of the Suk-Sai-Yat traditional Thai herbal remedy, Cannabis sativa oil (Deja formula) and lorazepam on sleep quality and quality of life in patients with chronic insomnia.

Methods: In a randomized controlled parallel-group trial, 60 adults with chronic insomnia received Suk-Sai-Yat, Cannabis sativa oil, or lorazepam for four weeks. Sleep quality was assessed using the Pittsburgh leep Quality Index (PSQI) and quality of life was evaluated using EQ-5D-5L and EQ-VAS. Safety was monitored throughout the study.

Results: After four weeks, PSQI scores significantly improved in all groups: Suk-Sai-Yat (12.3-6.6), Cannabis sativa oil (13.6-3.68) and lorazepam (14.4-5.8) (all p < 0.001), with no significant differences between groups. Quality-of-life scores improved significantly in the integrative therapy groups. Only mild adverse events were reported.

Conclusion: Suk-Sai-Yat and Cannabis sativa oil demonstrated comparable efficacy to lorazepam with favorable safety profiles, supporting their role as integrative, non-benzodiazepine options for chronic insomnia management.”

https://pubmed.ncbi.nlm.nih.gov/41623556

“Suk-Sai-Yat and Cannabis sativa oil significantly improved chronic insomnia symptoms.”

https://www.sciencedirect.com/science/article/pii/S2590142726000017?via%3Dihub