Evaluation of the role of striatal cannabinoid CB1 receptors on movement activity of parkinsonian rats induced by reserpine.

“It has been observed cannabinoid CB1 receptor signalling and the levels of endocannabinoid ligands significantly increased in the basal ganglia and cerebrospinal fluids of Parkinson’s disease (PD) patients. These evidences suggest that the blocking of cannabinoid CB1 receptors might be beneficial to improve movement disorders as a sign of PD…

 These results support this theory that cannabinoid CB1 receptor antagonists might be useful to alleviate movement disorder in PD…”

http://www.ncbi.nlm.nih.gov/pubmed/23960729

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