Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome.

“Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safety of cannabidiol added to a regimen of conventional antiepileptic medication to treat drop seizures in patients with the Lennox-Gastaut syndrome, a severe developmental epileptic encephalopathy. Among children and adults with the Lennox-Gastaut syndrome, the addition of cannabidiol at a dose of 10 mg or 20 mg per kilogram per day to a conventional antiepileptic regimen resulted in greater reductions in the frequency of drop seizures than placebo.” https://www.ncbi.nlm.nih.gov/pubmed/29768152 https://www.nejm.org/doi/10.1056/NEJMoa1714631]]>