“Background/Objectives: The use of cannabidiol (CBD) as an antimicrobial and antifungal agent has gained interest in medicine, with studies suggesting potential against various microorganisms. However, its effectiveness against oral pathogens remains underexplored in dental research, highlighting the need for further studies. This scoping review summarizes current evidence on the antimicrobial properties of CBD in dental and oral health.
Methods: A systematic search was conducted across seven databases (PubMed, the Cochrane Library, Scopus, Embase, Web of Science, SciELO, and LILACS) up to January 2025. The inclusion criteria encompassed studies that explored the effects of CBD on oral microbiology (in vitro and in vivo in animal models), regardless of language or year of publication. The gray literature was evaluated in the Google Scholar database.
Results: A total of 1284 articles were identified, of which 10 met the inclusion criteria for this scoping review. These studies, published between 2019 and 2025, primarily focused on bacterial and fungal cultures. The most commonly used methods were the minimum inhibitory concentration test and counting colony-forming units. The contact methods between CBD and bacterial/fungal cell cultures were either dilution or direct contact.
Conclusions: CBD shows promising antimicrobial properties against a range of oral bacteria and fungi, suggesting its potential application in managing oral health conditions.”
https://pubmed.ncbi.nlm.nih.gov/41294500
“The current knowledge regarding the microbiological properties of CBD indicates its antimicrobial potential against oral microorganisms such as P. gingivalis, S. mutans, and C. albicans. Several studies have evaluated CBD antimicrobial effects through assays such as the MIC test and bacterial growth assays, with varying concentrations and formulations. These studies suggest that CBD can inhibit microbial growth, though its effectiveness varies according to CBD concentration, microbial strain, and the delivery system.”