“A new series of cannabinol derivatives was synthesised and assessed for their inhibitory effects against α-glucosidase. Of nineteen derivatives evaluated, the brominated analogues (3a and 3b) demonstrated the most potent inhibition against rat intestinal α-glucosidase. Structure-activity relationship analysis suggested that the phenolic hydroxy group and the introduced bromine atoms play crucial roles in enhancing inhibitory potency. Enzyme kinetic studies further revealed that 3a and 3b retarded both maltase and sucrase via a non-competitive mechanism.”

https://pubmed.ncbi.nlm.nih.gov/41785417

https://www.tandfonline.com/doi/full/10.1080/14786419.2026.2638950

“Three new α-glucosidase inhibitors from aqueous extract of Cannabis sativa leaves: isolation, characterisation, and kinetic study”

https://pubmed.ncbi.nlm.nih.gov/39756038

“Alpha-glucosidase inhibitors are oral antidiabetic medications used to treat type 2 diabetes”