“Developmental and epileptic encephalopathies (DEEs) represent a group of disorders characterized by developmental slowing or regression together with seizures, that are often drug-resistant.”

“With this background, we investigated the effectiveness and tolerability of highly purified CBD in a cohort of monogenic DEEs, focusing on patients with highly active epilepsy.”

“Taken together, these findings suggest that CBD represents a valid therapeutic option for patients with DEEs and highly active epilepsy, providing meaningful seizure reduction even in the most treatment-refractory cases.”

“Our study shows that highly purified CBD may represent a feasible treatment option for patients with DEEs and highly active epilepsy.”

https://www.epilepsybehavior.com/article/S1525-5050(26)00157-5/fulltext