Hyperhidrosis can significantly affect daily life when excessive sweating persists despite standard treatment. This case report describes an unexpected improvement in hyperhidrosis following cannabidiol use, with the patient experiencing a noticeable reduction in sweating while taking CBD. The observation raises the possibility that cannabinoid signaling may influence autonomic pathways involved in sweat regulation. The report provides an unusual clinical signal that could justify further investigation of CBD in disorders of excessive sweating.
“Hyperhidrosis is characterized by excessive sweating and it affects almost 5% of the population. The affected age group is wide, and it can affect from children to elderlies. There are two types of hyperhidrosis: generalized and focal. Treatment depends on the symptoms presented. In more severe cases, radiofrequency sympatholysis and bilateral thoracic sympathectomy are the options. However, recurrence is possible or the postoperative appearance of conditions called compensatory hyperhidrosis or reflex hyperhidrosis.
We describe two cases of patients treated with Cannabidiol who had significant and unexpected improvement of hyperhidrosis.
The first patient received Cannabidiol specific for public presentations at work, and the second patient had a diagnosis of autism spectrum disorder.
The hyperhidrosis improved in both patients immediately after using Cannabidiol.”