“Bacterial infections can lead to wound inflammation and delay wound healing due to the cytotoxicity of the chemicals used in conventional wound dressings. Therefore, developing a new natural and non-toxic form of antibacterial hydrogel dressing is very important.
In this study, natural hemp fibers were used as the internal skeleton of hydrogels, combined with N-halamine antimicrobial nanosystems, and chitosan reaction was used to prepare Schiff base-type N-halamine hemp fiber-based hydrogels (N-hemp-gel).
This is mainly due to the unique polygonal cavity structure and phenolics of the hemp fibre itself, as well as the release of oxidized halide ions by N-halamine through electrostatic action, and the oxidation of bacterial enzymes and other intracellular compounds, which synergistically and significantly enhance the antimicrobial properties of the wound dressing.
Antimicrobial experiments showed that N-hemp-gel had significant bactericidal effects against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In a mouse model of infected wounds, N-hemp-gel showed a 100 % wound healing rate on day 7 with no visible scarring. Storage stability confirmed that the chlorine content of N-hemp-gel decreased by only 25.5 % after 30 days at room temperature. Renewability demonstrated that the chlorine content of N-hemp-gel decreased by only 0.54 % after ten cycles.
This natural hemp fibre hydrogel with excellent antimicrobial properties, good storage stability and renewability, and green environmental protection has a broad prospect in the field of wound dressing and biomedicine.”
“Hemp fibre belongs to the bast natural fibre, is extracted from the stem of the hemp plant, is the highest toughness of natural fibres, can be naturally decomposed green fibre, through photosynthesis can be renewable, and more than 60 kinds of unique phenolic substances in the hemp hemp fibre makes hemp fibre has excellent anti-bacterial and anti-inflammatory function.”
“In this study, N-halamine Schiff base type cannabinoid cellulose based hydrogels were successfully prepared.
Antibacterial assays demonstrated that the material exhibits significant antibacterial activity against E. coli and S. aureus, effectively addressing the innate lack of antibacterial properties in cellulose materials, while also offering good storage stability and renewability.”
https://www.sciencedirect.com/science/article/abs/pii/S0927775725009112