“Cannabidiol (CBD) has gained a lot of interest in recent years for its purported medicinal properties. CBD has been investigated for the treatment of anxiety, depression, epilepsy, neuroinflammation, and pain.
Recently there has been an interest in CBD as a possible treatment for age-related disorders such as Alzheimer’s disease and related disorders (ADRD). Here we tested the hypothesis that chronic CBD administration would improve learning and memory in the SAMP8 mouse model of Alzheimer’s disease.
SAMP8 mice aged 11 months (at the start of the study) were administered vehicle or CBD (3 or 30 mg/Kg) daily via oral gavage for 2 months. Vehicle-treated young SAMP8 mice (age 3 months at the start of the study) served as unimpaired controls. After 30 days of treatment (4 and 12 months of age), learning and memory, activity, anxiety, strength and dexterity were assessed.
High dose CBD treatment significantly improved learning and memory of the 12-month-old mice in the T maze. Novel object recognition memory was also improved by CBD in aged CBD treated mice. Aged CBD treated mice also displayed less anxiety in the elevated plus maze test compared to controls. However, activity and strength levels were similar between groups. Biochemical analysis revealed decreased markers of oxidative stress, providing a possible mechanism by which CBD treatment impacts learning, memory, and anxiety.
These results highlight the potential use of CBD as a therapeutic for age related cognitive impairment and dementia.”
https://pubmed.ncbi.nlm.nih.gov/40811673/
“Cannabidiol (CBD) is an abundant phytocannabinoid found in the Cannabis sativa plant.”
“CBD is thought by many to have medicinal properties. Except for a few conditions including two rare forms of epilepsy and multiple-sclerosis-associate spasticity, CBD has not been approved by the FDA”
“Here, we examine the potential use of CBD in treating age- related memory loss, anxiety, strength and dexterity impairment in the Senescence-accelerated mouse -prone 8(SAMP8) mice, a polygenic model of spontaneous onset AD.”
“Our results indicate that CBD can reverse age-related changes in the SAMP8 mice. CBD reversed memory impairment in both the T-maze and NOR with a 24-hour retention interval. These results indicate that CBD is able to reverse memory impairment in both spatial and recognition tasks. Taken together therefore, there appears to be an antioxidant effect of CBD contributing to the improvement in memory in the aged mice. These results show that CBD is an attractive therapeutic warranting further investigation in AD, and other neurodegenerative diseases.”
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0296586