“This study aimed to investigate the effects of hemp seed protein (HSP) on glucose and lipid metabolism and its possible mechanisms.

In a high-fat-induced mouse obesity model, HSP supplementation significantly reduced serum TC (Total cholesterol), TG (Triglycerides), and LDL-C (Low-density lipoprotein cholesterol) levels by 28 % (P < 0.001), 34 % (P < 0.001), and 40 % (P < 0.001) respectively, compared to the model group, while HDL-C (High-density lipoprotein cholesterol) increased by 77 % (P < 0.001).

Hepatic lipid accumulation was alleviated, and glucose tolerance and insulin sensitivity improved. In vitro, HSP hydrolysates exhibited stronger inhibitory activity against pancreatic α-amylase and lipase than HSP itself. Network pharmacology and molecular docking identified three hemp seed peptides from HSP hydrolysates, which interacted with AKT1, PPARG, and HMGCR.

These findings suggest that the metabolic regulatory effects of HSP are mediated by bioactive peptides that inhibit digestive enzymes and regulate AMPK-AKT1/PPARG/HMGCR metabolism pathway, providing insights into its potential as a functional health food.”

https://pubmed.ncbi.nlm.nih.gov/40279904/

https://www.sciencedirect.com/science/article/pii/S0308814625016577?via%3Dihub