“The global incidence of cancer continues to rise at an alarming rate, with annual cases projected to increase by 47% from 19.3 million in 2020 to 28.4 million by 2025.
Cannabis sativa L. was among the earliest plants investigated for potential anticancer therapies, due to its more than 100 bioactive constituents that confer notable antioxidant properties.
Hemp-derived extracts, particularly those rich in cannabidiol (CBD), exhibit notable synergistic biological effects, including the inhibition of cancer cell proliferation, angiogenesis, and metastasis, alongside the promotion of apoptosis.
These pharmacological attributes suggest that hemp oils may serve as promising alternatives or adjuncts to conventional chemotherapy, offering potential therapeutic benefits with a reduced risk of severe adverse effects.
This review discusses the current literature on hemp oils, with emphasis on their roles in cancer prevention, therapeutic efficacy, and potential toxicity in humans. Furthermore, it explores the various extraction methods employed in hemp oil production and examines their chemical compositions, offering a comprehensive understanding of the principal antioxidant constituents responsible for their bioactivity to the readers.”
https://pubmed.ncbi.nlm.nih.gov/40647426/
“Cancer is strongly associated with oxidative stress induced by free radicals, which damage cellular components, leading to genetic mutations, the disruption of normal cellular functions, and the promotion of carcinogenesis.
Hemp oils, which are rich in natural antioxidants such as cannabinoids, flavonoids, and terpenes, have been proposed as potential mediators to lessen oxidative stress and inhibit cancer progression by neutralizing free radicals and modulating biological pathways involved in cancer development.
This review presents a comprehensive analysis of the antioxidant and anticancer properties of hemp oils, with a particular focus on their potential role in cancer prevention and treatment in humans. It also addresses extraction techniques, chemical composition, therapeutic applications, and the potential toxicological risks associated with their use.”
“Hemp oils contain a complex matrix of bioactive compounds including cannabinoids, terpenes, flavonoids, and fatty acids that act synergistically to exert antioxidant and anticancer effects. Mechanistic studies demonstrate their ability to reduce oxidative stress, induce apoptosis, inhibit angiogenesis, and target cancer stem-like cells.’