“Microglia play dual roles after germinal matrix hemorrhage, and the neurotrophic phenotype maybe neuroprotective. We raise the hypothesis that a cannabinoid receptor2 agonist (JWH133) accelerates the CX3CR1⁺ microglia secreting neurotrophic factors and restores damaged neuronal circuit. Overall, this study provides evidence that JWH133 promoted a neurotrophic phenotype of microglia (CX3CR1⁺ microglia), beyond merely alleviating microglial proliferation and inflammation. Moreover, JWH133 restored impaired neuronal circuit, which represent a novel therapeutic strategy following GMH in clinic.” https://www.ncbi.nlm.nih.gov/pubmed/28153531]]>