“We recently reported that a CB₂R agonist, GW405833 (GW), reduced both the ACh-induced Ca²⁺ oscillations and the L-arginine-induced Ca²⁺ signal enhancement in mouse pancreatic acinar cells, suggesting that GW-induced inhibition may prevent the pathogenesis of acute pancreatitis. In this study, we aim to evaluate the effects of other cannabinoid ligands on Ca²⁺ signaling in acinar cells. In conclusion, CB₂R agonists play critical roles in modulating Ca²⁺ signals in mouse pancreatic acinar cells, while other cannabinoid ligands modulate Ca²⁺ oscillations in a heterogeneous manner through a CB receptor or non-CB-receptor mechanism.” https://www.ncbi.nlm.nih.gov/pubmed/30202013