Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study

Plos One | Publons

“Gramicidin is a monomeric protein that is thought to non-selectively conduct cationic currents and water. Linear gramicidin is considered an antibiotic. This function is considered to be mediated by the formation of pores within the lipid membrane, thereby killing bacterial cells.

The main non-psychoactive active constituent of the cannabis plant, cannabidiol (CBD), has recently gained interest, and is proposed to possess various potential therapeutic properties, including being an antibiotic. We previously determined that CBD’s activity on ion channels could be, in part, mediated by altering membrane biophysical properties, including elasticity.

In this study, our goal was to determine the empirical effects of CBD on gramicidin currents in human embryonic kidney (HEK) cells, seeking to infer potential direct compound-protein interactions. Our results indicate that gramicidin, when applied to the extracellular HEK cell membrane, followed by CBD perfusion, increases the gramicidin current.”

“One compound with amphiphilic properties is cannabidiol (CBD), the primary non-psychotropic constituent of Cannabis sativa. CBD is a clinically and experimentally substantiated therapeutic compound with efficacy against a variety of conditions, including seizure disorders (for which CBD is FDA-approved), pain, and muscle spasms. Furthermore, CBD has been suggested to have antibiotic properties.”

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