“Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic (OA) knees… application of the CB(1) agonist significantly reduced the firing rate of afferent nerve fibers… These findings indicate that activation of peripheral CB(1) receptors reduces the mechanosensitivity of afferent nerve fibers in control and OA knee joints. As such, peripheral CB(1) receptors may be important targets in controlling OA pain.”
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