“Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake.

Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC neurons.

We show that chemical promotion of CB1R activity increases feeding, and notably, CB1R activation also promotes neuronal activity of POMC cells…

Together, these results uncover a previously unsuspected role of POMC neurons in the promotion of feeding by cannabinoids.”

http://www.ncbi.nlm.nih.gov/pubmed/25707796

“Yale Study Finds “Marijuana Munchies” Linked to Brain Neurons”   http://wnpr.org/post/yale-study-finds-marijuana-munchies-linked-brain-neurons

“Mulling the marijuana munchies: How the brain flips the hunger switch” http://news.yale.edu/2015/02/18/mulling-marijuana-munchies-how-brain-flips-hunger-switch

“Effects Of Marijuana: Smoking Weed Gives You ‘The Munchies’ Because Of The Hunger Switch In Your Brain”  http://www.medicaldaily.com/effects-marijuana-smoking-weed-gives-you-munchies-because-hunger-switch-your-brain-322534