“Cannabis is a general name for plants of the genus Cannabis. Used as fiber, medicine, drug, for religious, therapeutic, and hedonistic purposes along the millenia, it is mostly known for its psychoactive properties. One of its major constituents, cannabidiol (CBD), a non-psychoactive substance, among many other biological activities, has shown potential as an anti-SARS-CoV-2 drug. In this work, three derivatives and an analogue of CBD were synthesized, and cell viability and antiviral activities were evaluated. None of the compounds showed cytotoxicity up to a maximum concentration of 100 μM and, in contrast, displayed a significant antiviral activity, superior to remdesivir and nafamostat mesylate, with IC50 values ranging from 9.4 to 1.9 μM. In order to search for a possible molecular target, the inhibitory activity of the compounds against ACE2 was investigated, with expressive results (IC50 ranging from 3.96 μM to 0.01 μM).”
https://pubmed.ncbi.nlm.nih.gov/37657273/
“Although specific antiviral drugs are available, COVID-19 treatment worldwide has not adhered to such available interventions due mostly because of lack of accessibility and cost-effectivity. Therefore, it is essential to search for alternatives in terms of antiviral compounds that would be effective in controlling SARS-CoV-2. In this context, cannabidiol (CBD), a non-psychoactive major constituent of Cannabis spp. plants, may contribute positively against COVID-19 by interfering with the mechanism of entry of the virus into the cell.”
https://www.sciencedirect.com/science/article/abs/pii/S0223523423007274?via%3Dihub