“Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa.” http://www.ncbi.nlm.nih.gov/pubmed/6491867

“Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines. We investigated the effects of a water-soluble extract of Maitake (Grifola frondosa), a Japanese edible mushroom, on the proliferation and cell death of four human gastric cancer cell lines. The Maitake extract (ME) inhibited the proliferation of all four cell lines in a time-dependent manner…these results suggest that ME induces apoptosis…resulting in potential antitumor effects on gastric cancer.” http://www.ncbi.nlm.nih.gov/pubmed/19639212

“Maitake extracts and their therapeutic potential…premier culinary as well as medicinal mushroom. Maitake is increasingly being recognized as a potent source of polysaccharide compounds with dramatic health-promoting potential…MD-fraction, and other extracts, often in combination with whole maitake powder, have shown particular promise as immunomodulating agents, and as an adjunct to cancer…” http://www.ncbi.nlm.nih.gov/pubmed/11207456

“Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tumor-bearing mice by enhancing the immune system…maitake D-Fraction appears to repress cancer progression…”  http://www.ncbi.nlm.nih.gov/pubmed/14977447

“Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells.” http://www.ncbi.nlm.nih.gov/pubmed/12499658

“Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis…D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities.”  http://www.ncbi.nlm.nih.gov/pubmed/11566496

“Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa…D-Fraction, a polysaccharide extracted from the maitake mushroom (Grifola frondosa), activates macrophages, dendritic cells, and T cells and inhibits the growth of tumor cells.”  http://www.ncbi.nlm.nih.gov/pubmed/15706424

“A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/20563803

“A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. Cancer patients commonly use dietary supplements to “boost immune function”. A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and therefore the potential for clinical use.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751581/

“Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells…For many years mushrooms have been used empirically in traditional medicine to treat several diseases…The identification of the molecular mechanisms by which D fraction exerts its effects is crucial for the development of preventive and therapeutic strategies for cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/21480800

“Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice. D-Fraction, a polysaccharide extracted from maitake mushrooms (Grifola frondosa), has been reported to exhibit an antitumor effect… These results suggest that D-Fraction can decrease the effective dosage in tumor-bearing mice by increasing the proliferation, differentiation, and activation of immunocompetent cells and thus provide a potential clinical benefit for patients with cancer.” http://www.ncbi.nlm.nih.gov/pubmed/15850970

“Antitumor activity of a beta-1,3-glucan obtained from liquid cultured mycelium of Grifola frondosa.” http://www.ncbi.nlm.nih.gov/pubmed/3820062

“Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan “grifolan LE” from Grifola frondosa.”  http://www.ncbi.nlm.nih.gov/pubmed/2805163

“Immunomodulating activities of cultivated maitake medicinal mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (higher Basidiomycetes)…Grifola frondosa is a culinary-medicinal mushroom that contains several physiologically active compounds, of which polysaccharides, specifically β-glucans, are known to possess immunomodulating properties…”  http://www.ncbi.nlm.nih.gov/pubmed/23510175

“Structure of a β-glucan from Grifola frondosa and its antitumor effect…This molecule could be a promising biological response modifier with clear application for antitumor therapies.”  http://www.ncbi.nlm.nih.gov/pubmed/22744837

“Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice. Maitake D (MD)-Fraction is a highly purified soluble β-glucan derived from Grifola frondosa (an oriental edible mushroom)…Our preclinical study suggests that MD-Fraction is a useful oral therapeutic agent in the management of patients with cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23280601

“Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa. These results suggested that grifolan NMF-5N shows antitumor activity via host-mediated mechanisms…”  http://www.ncbi.nlm.nih.gov/pubmed/3446772

“Anti-tumor effect of polysaccharide from Grifola frondosa and its influence on immunological function.” http://www.ncbi.nlm.nih.gov/pubmed/12858772

“Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice…D-Fraction, a polysaccharide extracted from the edible maitake mushroom (Grifola frondosa), activates immunocompetent cells, thereby eliciting antitumor activity… its administration may enhance host defense against foreign pathogens and protect healthy individuals from infectious diseases.”  http://www.ncbi.nlm.nih.gov/pubmed/15298759

“Preparation of a chemically sulfated polysaccharide derived from Grifola frondosa and its potential biological activities…combination might increase cytotoxic efficacy and decrease toxicity of some chemotherapeutic agents in cancer treatment.” http://www.ncbi.nlm.nih.gov/pubmed/16822541

“Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake).” http://www.ncbi.nlm.nih.gov/pubmed/3203420

“Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom)…”  http://www.ncbi.nlm.nih.gov/pubmed/11876556

“Potential growth inhibitory effect of maitake D-fraction on canine cancer cells… The postulated anticancer effect of D-fraction, the bioactive extract of maitake mushroom, on three types of canine cancer cells was evaluated… D-fraction was highly effective on the canine cancer cells, either potently inhibiting cell growth or directly killing cells. Similar effects were also demonstrated in certain human cancer cells… D-fraction is a potent natural agent that could be useful in treating canine cancers as well as other veterinary cancers.”  http://www.ncbi.nlm.nih.gov/pubmed/15719326

“Possible immunotherapeutic potentiation with D-fraction in prostate cancer cells.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613393/

“Inhibitory effect of MD-Fraction on tumor metastasis…The anti-metastatic activity of MD-Fraction extracted from the maitake mushroom (Grifola frondosa) was examined in an experimental murine model of lung metastasis…These results suggest that MD-Fraction inhibits tumor metastasis…”  http://www.ncbi.nlm.nih.gov/pubmed/18520039

“A heteropolysaccharide, L-fuco-D-manno-1,6-α-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative… tumor growth and metastasis are angiogenesis dependent, thus blockade of angiogenesis is a promising approach for treatment of cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/24299820

“Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa. A novel polysaccharide, MZF… was isolated from Grifola frondosa…These results indicate that MZF is a novel effective immunomodulator that has antitumor activity…” http://www.ncbi.nlm.nih.gov/pubmed/19839588

“Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa…clearly showed an inhibitory effect on tumor cell growth.”  http://www.ncbi.nlm.nih.gov/pubmed/20136432

“Enhancement of in vitro and in vivo anticancer activities of polysaccharide peptide from Grifola frondosa by chemical modifications.”  http://www.ncbi.nlm.nih.gov/pubmed/21595572

“Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells. Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer… According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appear to have significant anticancer activity. Altogether, these results suggest that Maitake D-Fraction could be a potential new target for breast cancer chemoprevention and treatment.”  http://www.ncbi.nlm.nih.gov/pubmed/23875900

“Possible disease remission in patient with invasive bladder cancer with D-fraction regimen…To our knowledge, this is the first and only case report of possible disease remission in a bladder cancer patient…it is conceivable that D-fraction is a natural agent that may have clinical implications in patients with superficial bladder tumors.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840560/