Shiitake mushrooms (Lentinus edodes)- Natural Antitumor Drug

“The cancer preventive effects of edible mushrooms.”  http://www.ncbi.nlm.nih.gov/pubmed/22583406

“Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms. Shiitake (Lentinus edodes) mushrooms have been reported to have cancer-preventing properties…These data suggest that inhibition of growth in tumor cells by “mycochemicals” in shiitake mushrooms may result from induction of apoptosis.”  http://www.ncbi.nlm.nih.gov/pubmed/16566671

“Selective induction of apoptosis in murine skin carcinoma cells by an ethanol extract of Lentinula edodes.” http://www.ncbi.nlm.nih.gov/pubmed/15737684

“Antitumor effect of virus-like particles from Lentinus edodes (Shiitake) on Ehrlich ascites carcinoma in mice.”  http://www.ncbi.nlm.nih.gov/pubmed/7271461

“Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). This study showed that the antitumor property of lentinan was maintained with oral administration.”  http://www.ncbi.nlm.nih.gov/pubmed/12470439

“The Use of Lentinan for Treating Gastric Cancer. Natural compounds containing fungal β-glucans have been used to improve general health for thousands of years…Lentinan…is one of the active ingredients purified from Shiitake mushrooms and has been approved as a biological response modifier for the treatment of gastric cancer in Japan.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664515/

“[Anti tumor activities of lentinan and micellapist in tumor-bearing mice]… Lentinan (LNT) is sold as a medicine, and Micellapist (MME) sold as a food supplement, both LNT and MME are beta-glucans isolated from the Shiitake mushroom (Lentinula edodes)…tumor growth was significantly suppressed…”  http://www.ncbi.nlm.nih.gov/pubmed/17212088

“Lentinula edodes mycelia (L.E.M.) is a dried powder extracted from shiitake mushrooms (Lentinula edodes)… Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line…may have potential chemotherapeutic applications for the treatment of HCC.”  http://www.ncbi.nlm.nih.gov/pubmed/22791146

“Lentinus edodes: a macrofungus with pharmacological activities…Antibiotic, anti-carcinogenic and antiviral compounds have been isolated…”  http://www.ncbi.nlm.nih.gov/pubmed/20491636

A novel polysaccharide from Lentinus edodes Mycelia exhibits potential antitumor activity…could be explored as a potential antitumor material…”  http://www.ncbi.nlm.nih.gov/pubmed/23955351

“Immunological study on the antitumor effects of fungus polysaccharides compounds.”  http://www.ncbi.nlm.nih.gov/pubmed/12725070

“Immunomodulation and anti-cancer activity of polysaccharide-protein complexes.”  http://www.ncbi.nlm.nih.gov/pubmed/10702635

“Effect of the culture extract of Lentinus edodes mycelia on splenic sympathetic activity and cancer cell proliferation…These findings suggest that L.E.M has an inhibitory effect on tumor proliferation…”  http://www.ncbi.nlm.nih.gov/pubmed/19059811

“Effects of lentinan alone and in combination with fluoropyrimidine anticancer agent on growth of human oral squamous cell carcinoma in vitro and in vivo. These findings demonstrate that the combination of Lentinan and S-1 is effective against OSCC and has the potential of being a new therapeutic tool for future treatment of these tumors.” http://www.ncbi.nlm.nih.gov/pubmed/20664931

“Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study.”  http://www.ncbi.nlm.nih.gov/pubmed/22126542

“An evidence-based review of a Lentinula edodes mushroom extract as complementary therapy in the surgical oncology patient.”  http://www.ncbi.nlm.nih.gov/pubmed/21628606

“Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.”  http://www.ncbi.nlm.nih.gov/pubmed/15630237

“In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes. Lentinula edodes, known as “shiitake” is one of the widely used medicinal mushrooms in the Orient. Antitumour activity of extracts of this mushroom has been widely demonstrated in animals and humans…  L. edodes aqueous extracts have demonstrated direct inhibition of the proliferation of human breast cancer cells in vitro and immunostimulatory properties…”  http://www.ncbi.nlm.nih.gov/pubmed/18242970

“Oral ingestion of Lentinula edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression.”  http://www.ncbi.nlm.nih.gov/pubmed/21261790

“Oral ingestion of Lentinula edodes mycelia extract can restore the antitumor T cell response of mice inoculated with colon-26 cells into the subserosal space of the cecum…oral ingestion of Lentinula edodes mycelia (L.E.M.) extract can inhibit the growth of a subcutaneously established melanoma…important implications for anticancer immunotherapy of human colon cancer.”  http://www.ncbi.nlm.nih.gov/pubmed/22086364

“Anticarcinogenic actions of water-soluble and alcohol-insoluble fractions from culture medium of Lentinus edodes mycelia.”  http://www.ncbi.nlm.nih.gov/pubmed/6891904

“Anticarcinogenic action of an alcohol-insoluble fraction (LAP1) from culture medium of Lentinus edodes mycelia.” http://www.ncbi.nlm.nih.gov/pubmed/4039972

“[Evaluation of quality of life and immune function in cancer patients receiving combined immunotherapy and oral administration of lentinula edodes mycelia extract]. In this study, we evaluated the quality of life (QOL) and immune function in cancer patients receiving a combination of immunotherapy and oral administration of Lentinula edodes mycelia extract (LEM)…Oral administration of LEM may improve QOL and immunity in patients receiving cancer immunotherapy.” http://www.ncbi.nlm.nih.gov/pubmed/23267884

“Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, fromLentinus edodes (Berk.) Sing. (an edible mushroom).”  http://www.ncbi.nlm.nih.gov/pubmed/5530561

“Purification, structural elucidation and antitumor activity of a novel mannogalactoglucan from the fruiting bodies of Lentinus edodes… should be explored as potential antitumor agents and could be potentially applied as a natural antitumor drug.” http://www.ncbi.nlm.nih.gov/pubmed/23262267

“Structure, chain conformation and antitumor activity of a novel polysaccharide from Lentinus edodes…could be potentially applied as a natural antitumor drug.”  http://www.ncbi.nlm.nih.gov/pubmed/20659533

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