Anti-cancer effects of Pleurotus ostreatus

“Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells… our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796484/

“An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects…Here, we describe a newly identified low-molecular-weight alpha-glucan with promising anti-tumorigenic properties, and demonstrate its direct effect on colon cancer cell proliferation via induction of programmed cell death.”  http://www.ncbi.nlm.nih.gov/pubmed/16413114

“Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans…proteoglycans derived from the mushroom (P. ostreatus) mycelia could be used as immunomodulators and anti cancer agents.” http://www.ncbi.nlm.nih.gov/pubmed/16782541

“Anti-inflammatory activity of edible oyster mushroom (Pleurotus ostreatus)… Mushrooms have been used, as a source of food and for their medicinal (generally anticancer) properties, since ancient times. A number of biologically active compounds, including polysaccharides, vitamins, terpenes, steroids, amino acids, and trace elements, have been identified in different mushroom species…In conclusion, the results of our study show that the edible oyster mushroom possesses anti-inflammatory activity. As such, the mushroom and its extract or concentrate, can be considered a functional food that has the potential to control inflammation.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120742/

“Anti-inflammatory plant natural products for cancer therapy.”http://www.ncbi.nlm.nih.gov/pubmed/20432202

“Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells. A water-soluble extract (POE) prepared from the fresh oyster mushroom Pleurotus ostreatus produced the most significant cytotoxicity on PC-3 cells among the mushroom species tested.”  http://www.ncbi.nlm.nih.gov/pubmed/16822205

“Effect of oyster mushroom (Pleurotus ostreatus) on pathological changes in dimethylhydrazine-induced rat coloncancer…a reduction in total number of tumours was observed in both groups of animals fed mushroom diet.”  http://www.ncbi.nlm.nih.gov/pubmed/9538185

“The role of apoptosis, proliferative cell nuclear antigen (PCNA) and p53 protein in the preventive effects of dietary fiber treated with the fungus Pleurotus ostreatus on rat-colon tumorigenesis was studied… corncob (treated with the fungus Pleurotus ostreatus) inhibits colon cancer development, and, therefore, may considered of potential use to the public.”  http://www.ncbi.nlm.nih.gov/pubmed/9216672

“Anti-Cancer Effects of Protein Extracts from… Pleurotus ostreatus…protein extracts of these mushrooms could be considered an important source of new anti-cancer drugs.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139501/

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