Anticancer effects of White button mushrooms (Agaricus bisporus)

“White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth… White button mushrooms are a widely consumed food containing phytochemicals beneficial to cancer prevention. The purpose of this research was to evaluate the effects of white button mushroom extract and its major component, conjugated linoleic acid (CLA) on prostate cancer cell lines in vitro and mushroom extract in vivo… The data provided by this study illustrate the anticancer potential of phytochemicals in mushroom extract both in vitro and in vivo and supports the recommendation of white button mushroom as a dietary component that may aid in the prevention of prostate cancer in men.” http://www.ncbi.nlm.nih.gov/pubmed/19005974

“Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus). White button mushrooms (Agaricus bisporous) are a potential breast cancer chemopreventive agent, as they suppress aromatase activity and estrogen biosynthesis. Therefore, we evaluated the activity of mushroom extracts in the estrogen receptor–positive/aromatase-positive MCF-7aro cell line in vitro and in vivo… our studies illustrate the anticancer activity in vitro and in vivo of mushroom extract and its major fatty acid constituents.” http://cancerres.aacrjournals.org/content/66/24/12026.long

“White Button Mushroom Phytochemicals Inhibit Aromatase Activity and Breast Cancer Cell Proliferation…Because natural compounds such as flavones and isoflavones have been shown to be inhibitors of aromatase, it is thought that vegetables that contain these phytochemicals can inhibit aromatase activity and suppress breast cancer cell proliferation…The white button mushroom (species Agaricus bisporus) suppressed aromatase activity dose dependently…Phytochemicals in the mushroom aqueous extract inhibited aromatase activity and proliferation of MCF-7aro cells. These results suggest that diets high in mushrooms may modulate the aromatase activity and function in chemoprevention in postmenopausal women by reducing the in situ production of estrogen.” http://jn.nutrition.org/content/131/12/3288.long

“Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporuswhite button mushrooms.Agaricus bisporus white button mushroom (WBM)… its dietary intake has been shown to protect against breast cancer. Mushroom polysaccharides are known for their immunomodulating and antitumor properties…our data provide a molecular basis to explain in part the reported beneficial therapeutic effects of A. bisporus WBM intake and suggest that macrophages likely contribute to the antitumor effects of Agaricus polysaccharides.” http://www.ncbi.nlm.nih.gov/pubmed/22217303

“Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity…isolated as a breakdown product of a secondary metabolite from the mushroom, Agaricus bisporus…The synthesized analogues were tested for anticancer activity… significant in vitro anticancer activity.” http://www.ncbi.nlm.nih.gov/pubmed/21046979

“Carcinogenicity examination of Agaricus bisporus, edible mushroom, in rats. Carcinogenicity of Agaricus bisporus, the edible mushroom, was studied in rats… No carcinogenic activity of A. bisporus was observed in this experiment.” http://www.ncbi.nlm.nih.gov/pubmed/2049788

“Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin…the edible mushroom Agaricus bisporus lectin (ABL)…A. bisporus lectin is a reversible noncytotoxic inhibitor of epithelial cell proliferation which deserves study as a potential agent for cancer therapy.” http://www.ncbi.nlm.nih.gov/pubmed/8402638

“Uses of plant lectins in bioscience and biomedicine.”  http://www.ncbi.nlm.nih.gov/pubmed/17981618

“The Antineoplastic Lectin of the Common Edible Mushroom (Agaricus bisporus) Has Two Binding Sites, Each Specific for a Different Configuration at a Single Epimeric Hydroxyl. The lectin from the common mushroom Agaricus bisporus, the most popular edible species in Western countries, has potent antiproliferative effects on human epithelial cancer cells, without any apparent cytotoxicity.” http://www.jbc.org/content/280/11/10614.long

“Lectin from Agaricus bisporus… Mushrooms have long been consumed not only for their dietary value, but also popularly as supplements for their medicinal properties. In recent years, attention has been focused on using mushrooms as antitumor agents and immunoregulators. Agaricus bisporus, commonly known as button mushroom or table mushroom, is the most widely consumed cultivated mushroom worldwide. Besides containing high amount of vitamins, extracts from the mushroom were found to exhibit chemopreventive, antiproliferative, and anti-inflammatory properties…Lectin from the edible mushroom Agaricus bisporus (ABL) was found to inhibit cell proliferation of some ocular and cancer cell lines.” http://www.iovs.org/content/53/12/7469.long

“Mushroom intake and risk of epithelial ovarian cancer in southern Chinese women…Intake of mushrooms, particularly white button mushroom, seemed to be inversely associated with the incidence of epithelial ovarian cancer in southern Chinese women.” http://www.ncbi.nlm.nih.gov/pubmed/24257554

“Edible Mushroom (Agaricus bisporus) Lectin, Which Reversibly Inhibits Epithelial Cell Proliferation, Blocks Nuclear Localization Sequence-dependent Nuclear Protein Import. The Galβ1–3GalNAcα (TF antigen)-binding lectin (ABL) from the common edible mushroom (Agaricus bisporus) has a potent anti-proliferative effect without any apparent cytotoxicity.” http://www.jbc.org/content/274/8/4890.long

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