Bladder function in a cannabinoid receptor type 1 knock-out mouse.

“OBJECTIVE: To evaluate bladder function in an established cannabinoid type 1 (CB1) receptor knock-out mouse model via organ bath (in vitro) and urodynamic (cystometric; in vivo) experiments.

CONCLUSIONS: In vitro, bladder strips from CB1 KO mice responded to muscarinic receptor stimulation similar to WT controls, but were less responsive to electrical stimulation of nerves. In vivo, CB1 KO mice had a higher micturition frequency and more spontaneous activity than WT animals.

The present findings suggest that CB1 receptors are involved in peripheral and central nervous control of micturition.”

“Cannabinoid receptor 1 also plays a role in healthy bladder.”

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