“Cannabis use has been associated with favorable outcomes on metabolic risk factors.
In this study we investigated whether this effect is mediated by the AKT1 gene, as activation of the related enzyme by cannabis may cause metabolic changes.
In conclusion, cannabis use is likely to be associated with a lower BMI in patients with a psychotic disorder.
Moreover, AKT1 risk alleles may increase the incidence of cannabis use in patients with a psychotic disorder, but AKT1 does not appear to mediate the effect of cannabis on BMI.”