“This study aimed to determine the cellular distribution of islet cannabinoid receptors (CBs) and their involvement in the development of metabolic and hormonal changes in rats fed a fructose-rich diet (F)…
Cannabinoid receptors appeared exclusively in islet α cells…
CONCLUSIONS:
Islet CBs would exert an important modulatory role in metabolic homeostasis…
Selective islet CB1 blockers could be useful to prevent/treat the alterations induced by the intake of unbalanced/unhealthy diets.”