Shared Predisposition in the Association Between Cannabis Use and Subcortical Brain Structure.

“OBJECTIVES: To determine whether cannabis use is associated with differences in brain structure in a large sample of twins/siblings and to examine sibling pairs discordant for cannabis use to separate potential causal and predispositional factors linking lifetime cannabis exposure to volumetric alterations.

CONCLUSIONS AND RELEVANCE: In this study, differences in amygdala volume in cannabis users were attributable to common predispositional factors, genetic or environmental in origin, with little support for causal influences.”

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