“The study was designed to investigate the effect of various concentrations of cannabidiol (CBD) in rats with chronic epilepsy.
The results revealed a significant decrease in the daily average grade of epileptic seizures on treatment with CBD (50 mg/kg).
The neuronal loss and astrocyte hyperplasia in the hippocampal area were also decreased.
CBD treatment did not affect the expression of iNOS in the hippocampus; however, the expression of NR1 was decreased significantly.
Thus, CBD administration inhibited the effect of pentylenetetrazole in rats, decreased the astrocytic hyperplasia, decreased neuronal damage in the hippocampus caused by seizures and selectively reduced the expression of the NR1 subunit of NMDA.
Therefore, CBD exhibits an anticonvulsive effect in the rats with chronic epilepsy.”
“Epilepsy is one of the most common diseases of the brain, affecting at least 50 million people globally… Despite development of a number of new antiepileptic drugs, epilepsy could not be significantly reduced and is a challenge to the clinicians… Many plants, known for their anticonvulsant activity are subjected to phytochemical and pharmacological studies. Cannabidiol (CBD) a constituent of the hemp seed exhibits potent anticonvulsant activity… The CBD possess anticonvulsive, anti-epileptic, and antimicrobial properties… The present study was performed to examine the anticonvulsive effects of CBD in pentylenetetrazole-induced chronic epilepsy rat models… The present study demonstrates that CBD protects against pentylenetetrazole-induced chronic seizures, decreases astrocytic hyperplasia, decreases neuronal cell loss and selectively suppresses NMDA1 receptor in the hippocampus… Therefore, CBD exhibits an anticonvulsive effect in the rats with chronic epilepsy.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537971/