Cannabinoid Receptor 1 and Acute Resistance Exercise – In vivo and In vitro Studies in Human Skeletal Muscle.

“This study aimed to determine whether cannabinoid receptor 1 (CB1) is involved in mammalian target of rapamycin (mTOR) signaling and skeletal muscle protein synthesis…

Our results indicate that RE down-regulates CB1 expression. Inhibition of CB1 signaling increases skeletal muscle anabolic signaling down-stream of mTOR and protein synthesis through ERK1/2.

Our study may provide base for the development of CB1-blocking drugs to treat or prevent muscle wasting.”

http://www.ncbi.nlm.nih.gov/pubmed/25796352

Leave a Reply

Your email address will not be published. Required fields are marked *