CB1 cannabinoid receptors are involved in neuroleptic-induced enhancement of brain neurotensin.

“Targeting the neuropeptide systems has been shown to be useful for the development of more effective antipsychotic drugs. Neurotensin, an endogenous neuropeptide, appears to be involved in the mechanism of action of antipsychotics…

Conclusion: The brain neurotensin under the regulatory action of CB1 receptors is involved inĀ  the effects of amisulpride and fluphenazine.”

http://www.ncbi.nlm.nih.gov/pubmed/24847420

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