Effect of anandamide in Plasmodium Berghei-infected mice.

“Eryptosis, the suicidal death of erythrocytes, is characterized by exposure of phosphatidylserine at the erythrocyte surface and cell shrinkage.

Triggers of eryptosis include anandamide.

Enhanced eryptosis of infected human erythrocytes is expected to delay the development of parasitaemia during infection with Plasmodium, the parasite causing malaria.

The present experiments aimed to test, whether anandamide influences eryptosis, parasite growth and/or host survival during in vitro or in vivo infection with Plasmodia.

In vivo administration of anandamide blunted the parasitaemia and significantly enhanced the survival of P. berghei-infected mice.

In conclusion, anandamide stimulated eryptosis of infected erythrocytes thus counteracting parasitaemia and a lethal course of the disease.”


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