“The antineoplastic drug 5-fluoruracil (5-FU) is a pirimidine analog, which frequently induces potentially fatal diarrhea and mucositis.
Cannabinoids reduce gastrointestinal motility and secretion and might prevent 5-FU-induced gut adverse effects.
Here, we asked whether cannabinoids may prevent diarrhea and mucositis induced by 5-FU in the rat.
CONCLUSIONS AND INFERENCES:
5-FU-induced diarrhea, but not mucositis, was partly prevented by WIN at a low dose.
Cannabinoids might be useful to prevent chemotherapy-induced diarrhea.”