[Neonatal hypoxia-ischemia: cellular and molecular brain damage and therapeutic modulation of neurogenesis].



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“Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. Neonatal encephalopathy affects to 1-3/1,000 newborns, leading to significant brain damage and childhood disability.

The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective.

The use of therapeutic agents such as erythropoietin and cannabinoids and mesenchymal stem cells have shown promising results in experimental models of perinatal asphyxia, being able of modulate neurogenesis, neuronal plasticity and neuroreparation processes after hypoxic-ischemic brain injury.”


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