“The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking.
We investigated the role of adult hippocampal neurogenesis in reducing cocaine voluntary intake produced by repeated cannabidiol treatment in mice.
Cannabidiol (20 mg/kg) reduced cocaine self-administration behaviour acquisition and total cocaine intake and enhanced adult hippocampal neurogenesis.
The present study confirms that adult hippocampal neurogenesis is one of the mechanisms by which cannabidiol lowers cocaine reinforcement and demonstrates the functional implication of adult hippocampal neurogenesis in cocaine voluntary consumption in mice.
Such findings highlight the possible use of cannabidiol for developing new pharmacotherapies to manage cocaine use disorders.”
“Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. Neonatal encephalopathy affects to 1-3/1,000 newborns, leading to significant brain damage and childhood disability.
The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective.
The use of therapeutic agents such as erythropoietin and cannabinoids and mesenchymal stem cells have shown promising results in experimental models of perinatal asphyxia, being able of modulate neurogenesis, neuronal plasticity and neuroreparation processes after hypoxic-ischemic brain injury.”
“Neurogenesis plays an indispensable role in the formation of the nervous system during development. The discovery that the adult brain still maintains neurogenic niches that allow the continued production of new cells after birth has changed the field of neuroscience. It has also opened a new venue of opportunities for the treatment of central nervous system disorders related to neuronal loss. This chapter has reviewed the studies showing that genetic or pharmacological manipulation of cannabinoid receptors (CB1 and CB2) or the enzymes responsible for endocannabinoid metabolism modify/regulate cell proliferation and neurogenesis during development and in the adult brain. A better characterization of the mechanisms involved in these effects could contribute to the development of new therapeutic alternatives to neurodegenerative and psychiatric disorders.”
“The cannabinoid system exerts functional regulation of neural stem cell (NSC) proliferation and adult neurogenesis, yet not all effects of cannabinoid-like compounds seen can be attributed to the cannabinoid 1 receptor (CB1 R) or cannabinoid 2 receptor (CB2 R).
The recently de-orphaned GPR55 has been shown to be activated by numerous cannabinoid ligands suggesting that GPR55 is a third cannabinoid receptor.
Here we examined the role of GPR55 activation in NSC proliferation and early adult neurogenesis.
CONCLUSIONS AND IMPLICATIONS:
Together, these findings suggest GPR55 activation as a novel target and strategy to regulate NSC proliferation and adult neurogenesis.”