“The endocannabinoid system (eCB) is a ubiquitous lipid signaling system composed of at least two receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. Within the brain, the eCB system is highly expressed in the hippocampus and controls basic biological processes, including neuronal proliferation, migration and differentiation, which are intimately linked with embryonal neurogenesis. Accumulated preclinical evidence has indicated that eCBs play a major role also in regulating adult neurogenesis. Increased cannabinoid receptor activity, either by increased eCB content or by pharmacological blockade of their degradation, produces neurogenic effects alongside rescue of phenotypes in animal models of different psychiatric and neurological disorders. Therefore, in the light of the higher therapeutic potential of adult neurogenesis compared to the embryonic one, here we sought to summarize the most recent evidence pointing towards a neurogenic role for eCBs in the adult brain, both under normal and pathological conditions.”
“The endocannabinoid system is involved in all aspects of the biology of neural stem cells. Selective CB1 and CB2 agonism produces pro-neurogenic effects in different models of brain insults. Further research is needed to characterize the eCB system as a new druggable target for neurogenesis-related diseases.”
“The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking.
We investigated the role of adult hippocampal neurogenesis in reducing cocaine voluntary intake produced by repeated cannabidiol treatment in mice.
Cannabidiol (20 mg/kg) reduced cocaine self-administration behaviour acquisition and total cocaine intake and enhanced adult hippocampal neurogenesis.
The present study confirms that adult hippocampal neurogenesis is one of the mechanisms by which cannabidiol lowers cocaine reinforcement and demonstrates the functional implication of adult hippocampal neurogenesis in cocaine voluntary consumption in mice.
Such findings highlight the possible use of cannabidiol for developing new pharmacotherapies to manage cocaine use disorders.”
“Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. Neonatal encephalopathy affects to 1-3/1,000 newborns, leading to significant brain damage and childhood disability.
The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective.
The use of therapeutic agents such as erythropoietin and cannabinoids and mesenchymal stem cells have shown promising results in experimental models of perinatal asphyxia, being able of modulate neurogenesis, neuronal plasticity and neuroreparation processes after hypoxic-ischemic brain injury.”
“Neurogenesis plays an indispensable role in the formation of the nervous system during development. The discovery that the adult brain still maintains neurogenic niches that allow the continued production of new cells after birth has changed the field of neuroscience. It has also opened a new venue of opportunities for the treatment of central nervous system disorders related to neuronal loss. This chapter has reviewed the studies showing that genetic or pharmacological manipulation of cannabinoid receptors (CB1 and CB2) or the enzymes responsible for endocannabinoid metabolism modify/regulate cell proliferation and neurogenesis during development and in the adult brain. A better characterization of the mechanisms involved in these effects could contribute to the development of new therapeutic alternatives to neurodegenerative and psychiatric disorders.”