Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis

“Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis…The endocannabinoid system and cannabimimetic compounds protect against effects of allergic inflammatory disorders in various species of mammals. Results of the present study contributed to knowledge of the endocannabinoid system and indicated this system may be a target for treatment of immune-mediated and inflammatory disorders such as allergic skin diseases in dogs.”

http://www.ncbi.nlm.nih.gov/pubmed/22738050

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The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia

“Hemp seed is rich in polyunsaturated fatty acids (PUFAs), which have potential as therapeutic compounds for the treatment of neurodegenerative and cardiovascular disease… potential candidates for the treatment of Alzheimer’s disease and cardiovascular disease.”

http://www.ncbi.nlm.nih.gov/pubmed/21331775 

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7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists

“Cannabinoid receptor agonists have gained attention as potential therapeutic targets of inflammatory and neuropathic pain. Here, we report the identification and optimization of a series of 7-oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamide derivatives as a novel chemotype of selective cannabinoid CB2 receptor agonists… 7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists.”

http://www.ncbi.nlm.nih.gov/pubmed/22738271

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Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress

“Cannabidiol (CBD) is the most abundant cannabinoid in Cannabis sativa that has no psychoactive properties. CBD has been approved to treat inflammation, pain and spasticity associated with multiple sclerosis (MS), of which demyelination and oligodendrocyte loss are hallmarks. Thus, we investigated the protective effects of CBD against the damage to oligodendrocyte progenitor cells (OPCs) mediated by the immune system… Cannabidiol protects oligodendrocyte progenitor cells… These findings suggest that attenuation of the ER stress pathway is involved in the ‘oligoprotective’ effects of CBD during inflammation.”

http://www.ncbi.nlm.nih.gov/pubmed/22739983

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Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon

“Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions…” and “Cannabinoid receptor activation induces apoptosis… in colon cancer cells”

http://www.ncbi.nlm.nih.gov/pubmed/19479993

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Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury

“Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury… These results demonstrate that the improvement in motor and autonomic function resulting from treatment with a selective CB2 agonist is associated with a significant effect on inflammatory responses in the spinal cord following injury.”

http://www.ncbi.nlm.nih.gov/pubmed/21970496

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Cannabinoids for gastrointestinal diseases: potential therapeutic applications

“…pharmacological modulation of the endogenous cannabinoid system could provide new therapeutics for the treatment of a number of gastrointestinal diseases, including nausea and vomiting, gastric ulcers, irritable bowel syndrome, Crohn’s disease, secretory diarrhoea, paralytic ileus and gastroesophageal reflux disease. Some cannabinoids are already in use…”

http://www.ncbi.nlm.nih.gov/pubmed/12517253

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Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases

“Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases… Many beneficial effects of herbal cannabinoids on gut motility and inflammation have been demonstrated, suggesting a vast potential for these compounds in the treatment of gastrointestinal disorders….endocannabinoid system’ (ECS), a cooperating network of molecules that regulate themetabolism of the body’s own and of exogenously administered cannabinoids. The ECS… offering many potential targets for pharmacological intervention. Of major therapeutic interest are nonpsychoactive cannabinoids that do not directly target cannabinoid receptors but still possess cannabinoid-like properties… promising alternative therapeutic tools to manipulate the ECS.”

http://www.ncbi.nlm.nih.gov/pubmed/21876860

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Normal Human Pituitary Gland and Pituitary Adenomas Express Cannabinoid Receptor Type 1 and Synthesize Endogenous Cannabinoids

“…we report for the first time the expression of CB1 in the human pituitary gland and human pituitary adenomas… cannabinoid-induced modulation of hormonal release were shown… these results indicate a potentially important role of the endocannabinoid system in pituitary pathophysiology, thus opening new perspectives in the management of pituitary adenomas… The results of this study point to a direct role of cannabinoids in the regulation of human pituitary hormone secretion.”

http://jcem.endojournals.org/content/86/6/2687.long

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Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease

CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases.”

http://www.ncbi.nlm.nih.gov/pubmed/21626285

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