Normal Human Pituitary Gland and Pituitary Adenomas Express Cannabinoid Receptor Type 1 and Synthesize Endogenous Cannabinoids

“…we report for the first time the expression of CB1 in the human pituitary gland and human pituitary adenomas… cannabinoid-induced modulation of hormonal release were shown… these results indicate a potentially important role of the endocannabinoid system in pituitary pathophysiology, thus opening new perspectives in the management of pituitary adenomas… The results of this study point to a direct role of cannabinoids in the regulation of human pituitary hormone secretion.”

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