“Alcohol use disorders affect millions of people worldwide and there is growing evidence that excessive alcohol intake causes severe damage to the brain of both humans and animals.
Numerous studies on chronic alcohol exposure in animal models have identified that many functional impairments are associated with the hippocampus, which is a structure exhibiting substantial vulnerability to alcohol exposure. However, the precise mechanisms that lead to structural and functional impairments of the hippocampus are poorly understood.
Herein, we report a novel cell death type, namely pyroptosis, which accounts for alcohol neurotoxicity in mice.
Conclusions: Alcohol induces hippocampal pyroptosis, which leads to neurotoxicity thereby indicating that pyroptosis may be an essential pathway involved in chronic alcohol-induced hippocampal neurotoxicity. Further, cannabinoid receptors are regulated during this process, which suggests promising therapeutic strategies against alcohol-induced neurotoxicity through pharmacologic inhibition of CB1R.”
“In the last years, clinical and preclinical researchers have increased their interest in non-psychotomimetic cannabinoids, like cannabidiol (CBD), as a strategy for treating psychostimulant use disorders. However, there are discrepancies in the pharmacological effects and brain targets of CBD.
“Opioid prescriptions and abuse remain a significant national concern.
“An emerging area of preclinical research has investigated whether drug use in parents prior to conception influences drug responsivity in their offspring.
“Four states have legalized medical cannabis for the purpose of treating opioid use disorder. It is unclear whether 
“People with spinal cord injuries (SCI) commonly experience pain and spasticity, but limitations of current treatments have generated interest in 
“Considering data from in vitro and in vivo studies, 
“To determine whether adjunctive dronabinol, a licensed form of delta-9-tetrahydrocannabinol, reduces opioid consumption when used off-label for managing acute pain following traumatic injury.