“Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization.
Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory.
The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia.
Topical cannabinoids reduce corneal hyperalgesia and inflammation.
The antinociceptive and anti-inflammatory effects of Δ8THC are mediated primarily via CB1R, whereas that of the cannabinoids CBD and HU-308, involve activation of 5-HT1A receptors and CB2Rs, respectively.
Cannabinoids could be a novel clinical therapy for corneal pain and inflammation resulting from ocular surface injury.”