Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans.

“Endocannabinoids may modify cancer development, progression and associated pain.

We determined whether cancer-evoked dysregulations in this system become manifest in altered tissue and plasma endocannabinoids…

 The endocannabinoid system was subject to cancer-associated regulations to an extent that led to measurable changes in circulating endocannabinoid levels, emphasizing the importance of the endocannabinoid system in the pathophysiology of cancer.”

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