The Lateral Habenula Directs Coping Styles Under Conditions of Stress Via Recruitment of the Endocannabinoid System.

Biological Psychiatry Home

“The ability to effectively cope with stress is a critical determinant of disease susceptibility.

The lateral habenula (LHb) and the endocannabinoid (ECB) system have independently been shown to be involved in the selection of stress coping strategies, yet the role of ECB signaling in the LHb remains unknown.


Alterations in LHb ECB signaling may be relevant for development of stress-related pathologies in which LHb dysfunction and stress-coping impairments are hallmark symptoms.”

“Cannabinoids¬†reverse the effects of early stress on neurocognitive performance in adulthood.”¬†

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