“Nicotine withdrawal is associated with cognitive deficits including attention, working memory, and episodic memory impairments.

Treatment with the non-psychoactive cannabinoid cannabidiol abolished memory impairment of nicotine withdrawal and microglia reactivity, reduced the expression of IL1β and IFNγ in the hippocampus and the prefrontal cortex, respectively, and normalized Ki67 levels. The nonsteroidal anti-inflammatory drug indomethacin also prevented cognitive deficits and microglial reactivity during withdrawal.

These data underline the usefulness of anti-inflammatory agents to improve cognitive performance during early nicotine abstinence.”

https://www.ncbi.nlm.nih.gov/pubmed/30391635

https://www.sciencedirect.com/science/article/pii/S0889159118302599?via%3Dihub