Cannabinoid Quinones-A Review and Novel Observations

molecules-logo“A cannabinoid anticancer para-quinone, HU-331, which was synthesized by our group five decades ago, was shown to have very high efficacy against human cancer cell lines in-vitro and against in-vivo grafts of human tumors in nude mice. The main mechanism was topoisomerase II╬▒ catalytic inhibition. Later, several groups synthesized related compounds. In the present presentation, we review the publications on compounds synthesized on the basis of HU-331, summarize their published activities and mechanisms of action and report the synthesis and action of novel quinones, thus expanding the structure-activity relationship in these series.”

https://pubmed.ncbi.nlm.nih.gov/33801057/

https://www.mdpi.com/1420-3049/26/6/1761

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